[Effect of graded exercise on arterial pressure and prostaglandin blood levels in hypertensive patients and those with neurocirculatory dystonia]. / Vplyv dozovanykh fizychnykh navantazhen' na riben' arterial'nogo tysku ta prostaglandyniv krovi khvorykh na gipertonichnu khvorobu ta v osib z neirotsyrkuliatornoiu dystoniieiu.

Effects were studied of graded veloergometer exercise on the level of arterial pressure and blood content of prostaglandins in patients with hypertensive disease (n = 14) and in persons with hypertonic type neurocirculatory dystonia (n = 22), who ranged from 17 to 19 years old. The reaction was different in the two groups: an increased diastolic pressure in hypertonic patients and decreased one in those with neurocirculatory dystonia, which event was accompanied by a striking (more than 2-fold) augmentation of the blood content of prostaglandins E. The data secured can be used in differential diagnosis of the above conditions.

[The role of the killer activity of the peripheral blood lymphocytes in the pathogenesis of rheumatism]. / Rol' killernoi aktivnosti limfotsitov perifericheskoi krovi v patogeneze revmatizma.

A total of 49 patients with rheumatism running a sluggish course, were examined, as were those with decompensated tonsillitis, systemic lupus erythematosus, and 20 essentially healthy subjects. In inactive rheumatism an increase in the killer activity of lymphocytes and augmentation of amounts of Fc+lymphocytes were revealed, which values were significantly different from those in the other groups. The detected changes in the activity of lymphocytes may serve as differential-diagnostic criteria.

[The level of serum thymic activity in patients with rheumatoid arthritis and systemic lupus erythematosus]. / Uroven' timicheskoi syvorotochnoi aktivnosti u bol'nykh revmatoidnym artritom i sistemnoi krasnoi volchankoi.

Thymic serum activity (TSA) has been studied in 52 healthy subjects, 48 rheumatoid arthritis patients and 17 sufferers with systemic lupus erythematosus aged from 18 to 70. TSA was compared in patients under and over 40 years. In those under 40 TSA appeared significantly inhibited, while in older subjects it did not differ from age-matched control. No correlations were reported between TSA levels and clinical characteristics. Changes in TSA levels may be related both to low content of thymic hormones and formation of inactive complexes from thymic mediators with inhibitors.

[The levels of circulating immune complexes and immunoglobulins in patients with systemic lupus erythematosus and rheumatoid arthritis]. / Urovni tsirkuliruiushchikh immunnykh kompleksov i immunoglobulinov u bol'nykh sistemnoi krasnoi volchankoi i revmatoidnym artritom.

UNLABELLED: The authors studied the levels of large- and medium molecular circulating immune complexes (CIC) and immunoglobulins of main classes (Ig) in 17 patients with systemic lupus erythematosus (SLE) and 47 patients with rheumatoid arthritis (RA). RESULTS: low molecular CIC increased in 35.2% of patients with SLE and in 42.5% with RA; patients with SLE showed a significant reduction of IgA in 80.4%. The IgA/IgM ratio was significantly reduced in SLE due to the above finding. The IgA level remained unchanged in RA.

[The etiology and pathogenesis of dilated cardiomyopathy]. / Ob étiologii i patogeneze dilatatsionnoi kardiomiopatii.

The authors analyze cardiomyopathies as primary lesions of the heart of unknown etiology. Examination of skin biopsies in patients with dilated cardiomyopathy indicates the presence of morphological signs of the systemic character of the process in the connective tissue, an increased content of circulating immune complexes in the blood of patients. In hypertrophic cardiomyopathy similar changes were found only in one patient. Dilated cardiomyopathy is a manifestation of a systemic immunopathological process in most of these patients.

[Relation of atherogenesis and T-immunodeficiency]. / Vzaimosvia'z aterogeneza i T-immunodefitsita.

Experiments on rabbits have shown that state of T-immunodeficiency induced by persisting virus infection promotes atherogenesis. Correction of age immunodeficiency by transplantation of the autologous bone marrow taken in young age considerably retards the atherosclerosis development. Inhibition of atherogenesis is also achieved by introduction (to animals) of natural thymic vilosene preparation which compensates a decrease in the functional activity of the thymus gland occurring under conditions of experimental hyperlipidemia.